Two things I notice some trouble with.
First, a small one. Obviously, I don't say "bless you" when someone sneezes. Why do people do this? Are they afraid you will die when you sneeze? I sneeze all the time and am still here. Once I was in line somewhere (fast food, or such) with the wife. She sneezed, I was silent. The woman in front of us just couldn't take it, and after a few itchy seconds turned around to bless her. From now on I plan to do as the Unitarians do, and say "ew, germs!"
Second, is a bigger one. Obviously I don't believe in prayer. Also, I am not comfortable providing empty hope. A virtual friend has a sick relative, and as far as I can go is "good luck." My desires will in no way influence the illness. I wish I could get away with "I'll pray for him," or other such nonsense. It would be easier. I would try to comfort through science, but those involved are being a bit of a pain. I also know better than to say "the doctors know what they are doing."
Society has ingrained so much of this into us. I at times feel callous because I was taught that being as I am is callous. Problem is, many of those responsible for my upbringing were/are superstitious fools.
So, in the case of my friend now, and in future situations, I will say, "I desire an outcome that will not cause you grief." It doesn't sound good, but is accurate.